The rate of change in breast density differed between women who developed breast cancer and those who did not.
Breast density is an established risk factor for the development of breast cancer, but changes in breast density over time and their correlation with risk is less clear due to limited investigation. Now, in a nested, case-control, cohort study, investigators examined changes in breast density using a sample from the Joanne Knight Breast Health Cohort of 10,481 women who were cancer-free at entry and were observed from 2008 to 2020 with screening mammograms every 1 to 2 years.
The study sample included 289 pathology-confirmed breast cancer cases and 658 controls matched for age and year of enrollment, with a total of 8710 mammograms. Most women were white (81%), 15% were Black. Most women in both the case and control groups were postmenopausa…
Reviewing Author
DisclosuresConsultant/Advisory BoardLilly; AstraZeneca; Gilead
Grant/Research SupportBreast Cancer Research Foundation
Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment
Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)
DisclosuresConsultant/Advisory BoardLilly; AstraZeneca; Gilead
Grant/Research SupportBreast Cancer Research Foundation
Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment
Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)