Breast-Conserving Therapy in Patients with Multiple Lesions

Lumpectomy followed by whole breast radiation therapy seems safe in women with multiple ipsilateral breast cancers.

The safety of breast-conserving therapy (BCT) in patients with multiple ipsilateral breast cancer (MIBC) had not been assessed in a prospective clinical trial. Now, in a prospective, phase 2, single-arm trial, investigators evaluated 5-year cumulative incidence of local recurrence (LR) in patients with MIBC undergoing BCT. Women aged ≥40 years with 2 or 3 foci of biopsy-proven cN0-1 breast cancer were enrolled between 2012 and 2016; in 2015, a requirement for preoperative breast MRI was lifted. Treatment entailed lumpectomy, with a requirement for negative margins, followed by whole breast radiation with a boost to each lumpectomy bed. A 5-year LR rate <8% was defined as “clinically acceptable” based on prior reported experience.

Of 270 wome…

Reviewing Author

William J. Gradishar, MD

Disclosures

Consultant/Advisory BoardLilly; AstraZeneca; Gilead

Grant/Research SupportBreast Cancer Research Foundation

Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment

Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)