Multifactorial Approach to Patients with Mild Cognitive Impairment

Various interventions, including aerobic or resistance exercise and cognitive training, benefit patients with mild cognitive impairment (MCI). Vitamin D supplementation also has been suggested to be beneficial. Canadian investigators explored various combinations of these three interventions by randomizing 175 older adults (mean age, 73; mean baseline vitamin D level, 30–35 ng/mL) with MCI to five arms. In four groups, all participants received aerobic/resistance exercise training plus either cognitive training or sham cognitive training, and either vitamin D or placebo. The fifth group was a control group.

All groups met thrice weekly (150 minutes per session) for 20 weeks. At 6 months, groups who received supervised exercise, with or witho…