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Data suggest that statins potentially could benefit many older adults, who have been underrepresented in clinical trials (NEJM JW Gen Med Jan 15 2021 and Lancet 2020; 396:1637). To clarify the relation between age and LDL-cholesterol response to statins, researchers in Denmark used nationwide databases to study 84,000 adults (≈10,000 were older than 75) who started taking simvastatin or atorvastatin between 2008 and 2018.
In patients who initiated low- or moderate-intensity statins, the magnitude of LDL-cholesterol reduction was greater among those 75 or older than among those 50 or younger. The difference in LDL-cholesterol reduction between the two age groups was 2.6 percentage points, equivalent to an absolute mean difference of ≈4 mg/dL.…