Another Failed Trial of Extracranial-to-Intracranial Bypass Surgery for Stroke Prevention

In a randomized study, there was no benefit at 2 years with ECIC bypass surgery.

Extracranial-to-intracranial (ECIC) artery bypass surgery has been proposed as a method to improve brain perfusion and prevent stroke. However, two major clinical trials in recent decades have not shown definite benefit with ECIC surgery in patients with internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion. These investigators conducted a randomized trial at 13 specialized centers in China to compare ECIC bypass surgery plus medical therapy with medical therapy alone. Patients were 18 to 65 years old and had an ICA or MCA occlusion and a history of stroke or transient ischemic attack (TIA) in the past 12 months. On imaging, study participants had a delay of >4 seconds on computed tomography perfusion and a cerebral blood …

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Another Failed Trial of Extracranial-to-Intracranial Bypass Surgery for Stroke Prevention

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Reviewing Author