A series of epidemiological investigations conducted in the U.K. suggest that the association may not be causal.
Fluoroquinolones have been associated with an excess risk of tendon rupture, presumably as a result of collagen degradation (NEJM JW Infect Dis Jul 12 2002 and BMJ 2002; 324:1306). More recently, fluoroquinolones were linked to excess risk of aortic aneurysm or dissection (NEJM JW Gen Med Mar 22 2018 and BMJ 2018; 360:k678, k988), leading the FDA to release drug safety notices. However, some studies question this association. Now, investigators have used data from two large U.K. primary care repositories to examine these associations using cohort and modified case-crossover study designs, ascertaining the outcome of hospitalization for aortic aneurysm or dissection using ICD-10 codes.
In the cohort study, comprising nearly 3.6 million indivi…
Reviewing Author
DisclosuresGrant/Research SupportBrigham and Women’s Hospital; American Heart Association and VIVA Physicians
Editorial BoardsThrombosis Research; Thrombosis and Haemostasis; Journal of the American College of Cardiology
Leadership Positions in Professional SocietiesSociety for Vascular Medicine (Research, Quality, and Publications Committee member); International Society on Thrombosis and Haemostasis
DisclosuresGrant/Research SupportBrigham and Women’s Hospital; American Heart Association and VIVA Physicians
Editorial BoardsThrombosis Research; Thrombosis and Haemostasis; Journal of the American College of Cardiology
Leadership Positions in Professional SocietiesSociety for Vascular Medicine (Research, Quality, and Publications Committee member); International Society on Thrombosis and Haemostasis