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NEJM Journal Watch has brought you coverage of study findings presented at the European Society of Cardiology's annual meeting. Here is a compilation of our coverage, listed by title of NEJM Journal Watch summary, with the study article's first author in parentheses. (Your NEJM Journal Watch subscription is required.)
GLP-1 Agonist Therapy for Heart Failure with Preserved Ejection Fraction and Obesity (Kosiborod MN)
An industry-sponsored trial shows encouraging efficacy and safety of semaglutide for improving HFpEF symptoms and functioning. Read the summary.
ECMO Strikes Out in Patients with Acute Myocardial Infarction and Cardiogenic Shock (Thiele H)
A major randomized trial showed no mortality difference with extracorporeal membrane oxygenation versus supportive care alone. Read the summary.
Complete Revascularization Beats Culprit-Lesion–Only in Older Patients with Myocardial Infarction (Biscaglia S)
A lower rate of adverse cardiovascular events was demonstrated with physiology-guided complete revascularization at 1 year postprocedure. Read the summary.
A “Negative” Trial of Intravenous Iron Replacement in Heart Failure with Reduced Ejection Fraction (Mentz RJ)
Another trial, this one showing no clear benefit. Read the summary.
Catheter Ablation Again Shows Benefit in Patients with Atrial Fibrillation and Heart Failure (Sohns C)
The procedure improved clinical outcomes, including all-cause mortality, in patients referred for heart transplantation evaluation. Read the summary.
A Head-To-Head Contest: Pulsed Field Ablation vs. Thermal Ablation in Patients with Atrial Fibrillation (Reddy VY)
The ablation techniques were roughly equivalent in effectiveness and safety. Read the summary.
Should Patients with Atrial High-Rate Episodes Without Atrial Fibrillation Receive Anticoagulation? (Kirchhof P)
Edoxaban did not benefit older adults at risk for stroke who did not have AF on surface ECG and led to excess major bleeding events. Read the summary.
What's the Optimal Timing of Complete Revascularization for STEMI with Multivessel Disease? (Stähli BE)
No, based on 2-year outcomes in a randomized study of routine testing at 1 year. Read the summary.
Optical Coherence Tomography Guidance for Percutaneous Coronary Intervention (Ali ZA)
Despite an improvement in technical outcomes, optical coherence tomography guidance did not result in improved clinical outcomes for patients undergoing complex PCI. Read the summary.
The Worldwide Impact of Modifiable Cardiovascular Risk Factors (The Global Cardiovascular Risk Consortium)
Quantifying the region- and sex-specific consequences of these risk factors can help to shape policy efforts and patient care. Read the summary.