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Because gout is an inflammatory condition that usually involves the lower extremities, one might wonder whether an acute flare predisposes a patient to venous thrombosis — either by creating a local thrombogenic state or by immobilizing the limb due to pain. In this study, U.K. researchers did a “self-controlled case series” study of 314 patients who had acute gout flares and episodes of venous thromboembolism (VTE) during the 2 years before or after their gout flares. The goal was to determine whether VTE incidence increased transiently during the 90 days after a gout flare, compared with baseline periods (preflare and >90 days postflare).
Risk for VTE increased significantly within the 30 days after a gout flare, compared with baseline per…