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Neurofilament light chain (NfL) has emerged as a marker of neuronal damage that is expressed in neurons of the central and peripheral nervous system. Peripherin, a type III intermediate filament, may be a more specific candidate marker for peripheral nervous system pathology because of its almost exclusive expression in peripheral nerve axons. To explore this possibility, investigators performed immunostaining on rat tissues, induced in vitro axonal injury and demyelination, developed an immunoassay to detect serum peripherin using single molecule array technology (Simoa), and then compared longitudinal serum peripherin and NfL in 45 patients with Guillain-Barré syndrome (GBS), 35 with chronic inflammatory demyelinating polyradiculoneuropat…