Potential Benefit from Imaging-Guided Late Thrombolysis for Stroke

Using imaging to define a tissue clock may be useful for intravenous thrombolysis decisions.

Traditionally, the time from last known well has been used to identify patients who present within 4.5 hours after ischemic stroke onset and, therefore, are potential candidates for intravenous thrombolysis (IVT). However, imaging tools such as computed tomographic (CT) perfusion mismatch could identify patients beyond 4.5 hours who might benefit from IVT. These authors studied both CT perfusion mismatch and novel imaging parameter, net water uptake (NWU) in the region of ischemia. Low NWU values have been associated with better outcomes. They identified 409 patients (median age, 76 years; 53% women) with anterior circulation large- vessel occlusion who were candidates for thrombectomy, identified during a 6-year period at a single center. …

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Potential Benefit from Imaging-Guided Late Thrombolysis for Stroke

Topics

Reviewing Author