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Rapid overcorrection of hyponatremia has been associated with osmotic demyelination syndrome (ODS), but data also suggest that correcting sodium slowly might be associated with longer hospital length of stay and excess in-hospital mortality. To examine the relation between serum sodium correction rates and clinical outcomes, researchers performed a retrospective study of more than 3000 patients with severe hyponatremia (<120 mEq/L) who were admitted to two Massachusetts hospitals during a 25-year period.
The cohort was divided into three groups according to calculated correction rates: Slow (<6 mEq/L/24 hours), moderate (6 to 10 mEq/L/24 hours), and fast (>10 mEq/L/24 hours). About one third of the cohort fell into each group. The moderate-c…