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The 2017 American College of Cardiology/American Heart Association high blood pressure guidelines lowered the definition of hypertension to 130/80, yet blood pressure control in the U.S. has worsened since that time, even by the old definition of 140/90. Some clinicians may have concerns about the lower threshold, particularly for people with baseline orthostatic hypotension. To address this issue, investigators conducted a participant-level meta-analysis of 9 blood pressure trials that assessed the new blood pressure goals or an active agent and included assessments of orthostatic hypotension.
The 9 trials included 29,235 participants (mean age, 69 years; 48% women) followed for a median of 4 years. At baseline, 9% had orthostatic hypotensi…