Chronic Pain and Its Association with Cerebrospinal Fluid Biomarkers of Neurodegeneration

Chronic pain was associated with differences in CSF biomarkers when compared with those without chronic pain in a large study.

An association between chronic pain and cognitive decline has not been well established. In this study, researchers analyzed data from the Alzheimer's Disease (AD) Neuroimaging Initiative to assess whether chronic pain was associated with cerebrospinal fluid (CSF) biomarkers for neurodegeneration and neuroinflammation. Based on the amyloid, tau, neurodegeneration (ATN) classification scheme and using CSF amyloid-beta 1-42 (Aβ1-42), phosphorylated-tau 181 (p-tau181), and total tau (t-tau) levels, participants were either on the AD continuum (amyloid-positive with or without neurodegeneration biomarkers), had suspected non-AD pathophysiology (SNAP; amyloid-negative with neurodegenerative-positive biomarkers), or lacked both amyloid and neurod…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Chronic Pain and Its Association with Cerebrospinal Fluid Biomarkers of Neurodegeneration

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Reviewing Author