Does Fecal Microbiota Transplantation Have Applications Beyond Recurrent Clostridioides difficile?

In a pilot study, FMT eliminated intestinal colonization with multi-drug resistant organisms in most kidney transplant recipients.

The WHO includes antimicrobial resistance among the top ten threats to global health. Susceptible populations include those heavily treated with antibiotics, in whom intestinal colonization with multi-drug resistant organisms (MDROs) often precedes disease. Now, investigators report on fecal microbiota transplantation (FMT) as an innovative strategy to address colonization with MDROs beyond Clostridioides difficile.

Eleven kidney transplant recipients (KTRs) with MDRO stool colonization and a history of infections caused by MDROs were randomized 1:1 to bowel preparation with FMT (delivered by enema) versus bowel preparation alone. Participants were tested every 36 days for intestinal colonization with MDROs; those with persistent colonizatio…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Does Fecal Microbiota Transplantation Have Applications Beyond Recurrent Clostridioides difficile?

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Reviewing Author