Streptococcal Prosthetic Valve Endocarditis — Antibiotic Treatment for 4 or 6 Weeks?

In a retrospective multicenter cohort study in France, 4 weeks of treatment was not inferior to the recommended 6-week course.

Prosthetic valve endocarditis (PVE) is difficult to treat, with streptococci comprising more than one third of causative pathogens and in-hospital mortality approaching 50%. Endocarditis guidelines of the American Heart Association and the European Society of Cardiology recommend 6 weeks of intravenous antibiotic treatment for streptococcal PVE, considerably longer than the suggested 2 to 4 weeks for streptococcal native valve endocarditis. But is longer better?

French researchers conducted a retrospective analysis of 121 patients (median age, 72; 62% male) with streptococcal PVE treated from 2001–2021 at three cardiac surgery centers in Paris. PVE primarily affected aortic (70%), pulmonary (17%), mitral (12%), and tricuspid (2%) valves and …

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Streptococcal Prosthetic Valve Endocarditis — Antibiotic Treatment for 4 or 6 Weeks?

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Reviewing Author