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Although thiazide-induced hyponatremia traditionally has been considered to be very uncommon, clinical experience suggests otherwise. In a retrospective cohort, investigators used a Danish national registry to assess the frequency of new hyponatremia (Na level, <130 mmol/L) among patients who initiated antihypertensive therapy with a thiazide diuretic or a combined thiazide–renin-angiotensin system (RAS) inhibitor. The control group was patients who initiated either a calcium-channel blocker or a RAS inhibitor alone. Two-year cumulative incidence outcomes were reported.
Incidence of hyponatremia was significantly higher among 50,000 patients who initiated antihypertensive therapy with thiazide diuretics or combined thiazide-RAS inhibitors th…