Initiating Treatment for Hepatitis C Infection During Hospitalization

In a small Norwegian trial, in-hospital HCV testing and treatment led to higher likelihood of therapy initiation and completion but no difference in sustained viral response at 4 weeks.

Despite the availability of safe and effective direct-acting antivirals for treating hepatitis C virus (HCV) infection, the prevalence of such infection has not declined. The typical model for HCV treatment — outpatient referral — may not reach the marginalized populations at risk. To examine the effect of testing and then initiating HCV treatment during hospitalization, Norwegian investigators designed OPPORTUNI-C, an open-label, multicenter trial conducted between October 2019 and December 2021. Seven clinical clusters within the hospital were randomly assigned to switch from no treatment (control) to starting treatment in-hospital (intervention). Two hundred participants (among 341 eligible individuals) with detectable HCV RNA on admissi…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Initiating Treatment for Hepatitis C Infection During Hospitalization

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Reviewing Author