Macronutrients Associated with Slower Disease Progression in Patients with ALS

An observational study linked higher glycemic index and glycemic load to slower ALS progression.

Weight loss in patients often precedes the onset of amyotrophic lateral sclerosis (ALS) and is associated with faster disease progression and shorter survival. The underlying mechanisms are not clearly defined. To examine the relationship between dietary components (including calories, carbohydrates, fat, fiber, protein, glycemic index [GI], and glycemic load [GL]) and ALS progression and survival, researchers analyzed data from 304 patients enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Participants (mean age, 62; mean disease duration, 12 months) completed an 85-item self-administered questionnaire on eating habits in the previous 6 months.

Higher GI and GL were associated with slower disease progression in …

Reviewing Author

Leana Doherty, MD

Disclosures

Editorial BoardsNeurohospitalist Society; InterACTN (Annals of Clinical and Translational Neurology)

Leana Doherty, MD

Disclosures

Editorial BoardsNeurohospitalist Society; InterACTN (Annals of Clinical and Translational Neurology)

Macronutrients Associated with Slower Disease Progression in Patients with ALS

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Reviewing Author