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Prosthetic joint infections (PJIs) are costly, protracted, and cumbersome, especially when compounded by parenteral antimicrobial regimens. Evidence suggests that shorter antibiotic courses and early oral antibiotic therapy (OAT) may provide similar outcomes as prolonged intravenous courses, although results have been inconsistent.
Investigators in France performed a multisite retrospective study involving 172 patients (60% male) and 38 orthopedic surgeons. PJI most often affected the knee (50%) and hip (35%), and Staphylococcus spp. comprised the most common pathogen genus. In 76% of patients, implants were retained after surgical debridement. Most patients (77%) initially received parenteral antibiotic therapy (typically daptomycin plus pi…