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Soft-tissue infections are among the most common reasons for prescribing antibiotics. Treatment decisions are often empiric, with drug selection leaning toward beta-hemolytic streptococci in nonpurulent infection and Staphylococcus aureus in purulent infection. However, uncertainty around the effectiveness of tetracycline and trimethoprim/sulfamethoxazole (TMP/SMX) against streptococci has prompted use of cumbersome oral antibiotic regimens that challenge adherence.
In a retrospective single-center cohort study involving 100 patients presenting to an emergency department in Phoenix with new nonpurulent cellulitis and treated as outpatients with <14 days of oral doxycycline or cephalexin, Taylor et al. assessed clinical failure (requirement f…