For Managing Febrile Urinary Tract Infections in Young Children, Shorter Duration May Be Better — or at Least as Good

In a randomized trial in Italy, 5 days of an oral antibiotic was as effective as 10 days.

Most children with uncomplicated febrile urinary tract infection (UTI) receive oral antibiotics, typically for 10 days. But is this traditional duration evidence based? In a multicenter trial, Italian investigators assessed recurrent infection within 30 days of completing 5-day versus 10-day treatment courses. Secondary end points were clinical response, adverse events, and antibiotic resistance.

In all, 140 children with febrile UTIs were randomized 1:1 on day 5 of antibiotic treatment (amoxicillin-clavulanate) to either stopping therapy or adding an additional 5 days of antibiotics, with follow-up for microscopic urine examination 5 and 30 days, respectively, after antibiotic completion. Key findings were:

E. coli was the primary causative …

Reviewing Author

Deborah Lehman, MD

Disclosures

Nothing to disclose

Deborah Lehman, MD

Disclosures

Nothing to disclose

For Managing Febrile Urinary Tract Infections in Young Children, Shorter Duration May Be Better — or at Least as Good

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Reviewing Author