Dual-Target Adaptive Deep Brain Stimulation for Parkinson Disease

In a proof-of-concept study, investigators were able to adjust settings automatically and proportionally in the outpatient setting.

The use of continuous deep brain stimulation (cDBS) of both the subthalamic nucleus (STN) and globus pallidus internus (GPi) has been shown effective for well-selected persons with Parkinson disease (PD) requiring a surgical intervention. These authors were interested in simultaneous benefit of using both regions, and they further explored the use of adaptive DBS (aDBS) techniques. The authors implanted bilateral DBS of both STN and GPi targets in six individuals. They reported data on dual-target cDBS that was collected over a 2-year period. The authors then applied proportional-plus-integral aDBS continuously in the home setting. Proportional-plus- integral was the automated programming the investigators used to set the device for what wa…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)