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Although current estimates regarding the impact of fungal infections on human health are imprecise, such figures are critical for public health planning, diagnostic implementation, and development of antifungal therapeutics. Accordingly, Denning reviewed publications from 2013 to 2023 along with references cited in major reviews to define the populations at risk, annual incidence, and attributable mortality of fungal illness worldwide.
Each year, over 6.5 million persons contract life-threatening fungal infections with 2.5 million attributable deaths. The annual global incidence of invasive aspergillosis was estimated at >2 million with a mortality of 1.8 million. For Candida bloodstream infections, annual incidence was about 626,000. In add…