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About 50% of cervical intraepithelial neoplasia grade 2 (CIN2) lesions regress spontaneously. One question is whether vaccination against human papillomavirus (HPV) — which lowers risk for developing cervical cancer — also lowers risk for progression from CIN2 to a grade 3 lesion or cancer. To address this question, Danish researchers analyzed a population-based cohort of almost 8000 women who were receiving active surveillance of CIN2 lesions; active surveillance consisted of semiannual colposcopy with cytology, with or without cervical biopsies. Almost 50% of patients had received at least one HPV vaccination prior to CIN2 diagnosis. CIN2 persistence at 24 months was an indication for a loop electrosurgical excision procedure.
During 28 mo…