Cerebral Amyloid Angiopathy and Risk for Subdural Hemorrhage

In two large studies, rates of subdural hemorrhage were increased in patients with cerebral amyloid angiopathy.

Cerebral amyloid angiopathy (CAA) is a well-known risk factor for intracerebral hemorrhage and sulcal subarachnoid hemorrhage. Whether CAA is related to subdural hemorrhage (SDH) is not clear. In this analysis, researchers analyzed two large, community-based prospective research studies: the UK Biobank study (2006–2022) and the All of Us research project in the U.S. (2018–2022). They identified patients with an administrative diagnosis code for CAA and assessed the rate of SDH in these patients, after adjustment for key clinical variables.

In the UK Biobank cohort (mean age, 56.5 years; 54% women), there were 649 SDH cases and 126 patients identified with CAA. Among the patients with CAA, 3 were diagnosed with SDH. In the second cohort (mean…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Cerebral Amyloid Angiopathy and Risk for Subdural Hemorrhage

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Reviewing Author