Single-Dose Oral Cholera Vaccination: Protection in an Endemic Area

One dose of cholera vaccine (intended as a two-dose regimen) provided substantial protection for at least 3 years in recipients aged ≥5 years in the DRC.

Cholera vaccine doses in the emergency stockpile fell far short of those requested in 2022, prompting a policy change so that the standard two-dose regimen was replaced with one dose during outbreaks. But is a single dose effective? Following flooding in 2020, an emergency mass cholera vaccination campaign was conducted in the Democratic Republic of the Congo (DRC). Now, Malembaka and colleagues have assessed the effectiveness of a single-dose regimen using killed oral cholera vaccine (kOCV; Euvichol-Plus), the only WHO-prequalified kOCV available globally. In Uvira (DRC), vaccination was offered to individuals aged ≥1 year; about a third reportedly received one dose.

After the mass vaccination campaign, two cholera outbreaks occurred. The i…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Single-Dose Oral Cholera Vaccination: Protection in an Endemic Area

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Reviewing Author