Is Cytomegalovirus Disease a Risk Factor for Chronic Lung Allograft Dysfunction After Transplantation?

In a large cohort study, high- or intermediate-risk cytomegalovirus serostatus (but not DNAemia) was associated with chronic lung allograft dysfunction.

Despite preventive strategies, cytomegalovirus (CMV) remains a leading cause of disease after solid organ transplantation. Indirect effects of CMV infection include organ-specific complications (e.g., chronic allograft nephropathy, cardiac vasculopathy) as well as more-general effects including excess risk for rejection and death. After lung transplantation, chronic lung allograft dysfunction (CLAD) is the most important limitation to long-term survival. Thus, investigators sought to determine the role of CMV in CLAD.

Among 668 lung transplant recipients, 647 had evaluable data. CLAD developed in 39% and was associated with high-risk (CMV donor positive/recipient negative) serostatus and, to a lesser degree, intermediate-risk (CMV recipient …

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Is Cytomegalovirus Disease a Risk Factor for Chronic Lung Allograft Dysfunction After Transplantation?

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Reviewing Author