What Is the Long-Term Effectiveness of Tuberculosis Preventive Therapy?

Extended follow-up in two Brazilian trials of TPT indicates that protection was sustained for up to 12 years.

Given that most individuals with latent tuberculosis (TB) will never go on to develop clinical disease, a key question for these patients concerns the relative risks and benefits of tuberculosis preventive therapy (TPT) with either rifampin for 4 months or isoniazid for 9 months. Researchers now report an analysis of the longer-term outcomes in Brazilian subjects who had been enrolled in two multinational trials (one in pediatric patients and the other in adults) that initially compare these two regimens through 16 and 28 months of follow-up.

Among 991 evaluable participants (median follow-up, 9.6 years), most were HIV-negative and were receiving TPT after documented contact with an individual who had active TB. Sixteen subjects developed cl…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

What Is the Long-Term Effectiveness of Tuberculosis Preventive Therapy?

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Reviewing Author