COVID-19 Vaccine Protects Against Multisystem Inflammatory Syndrome in Children

In 2023, children vaccinated against COVID-19 were less likely to develop MIS-C following infection with SARS-CoV-2.

Multisystem inflammatory syndrome in children (MIS-C) is a multiorgan inflammatory condition that follows primary or recurrent SARS-CoV-2 infection (NEJM JW Infect Dis Jun 17 2020 and JAMA 2020; 324:259 and 294). Rates of MIS-C were highest during the early months of the pandemic; thereafter, reported peaks mirrored COVID-19 activity.

Now, CDC authors describe 117 children who met the 2023 CDC case definition of MIS-C (with onset in 2023; mean age, 7 years). Overall incidence was 0.11 cases per million person-months, a significant decline from the peak months in 2022 (0.56 per million person-months) and 2020 (6.79 per million person-months). Despite 96% of patients being age-eligible, only 18% had received any COVID-19 vaccination. Of the va…

Reviewing Author

Deborah Lehman, MD

Disclosures

Nothing to disclose

Deborah Lehman, MD

Disclosures

Nothing to disclose

COVID-19 Vaccine Protects Against Multisystem Inflammatory Syndrome in Children

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Reviewing Author