COVID-19 Risk and Outcomes Among Solid Organ Transplant Recipients: A Mixed Picture

While outcomes are far better than early in the pandemic, many SOTRs remain at excess risk for severe COVID-19.

Clinicians caring for solid organ transplant recipients (SOTRs) with COVID-19 need information about their patients' risk for severe disease progression to provide optimal advice regarding early antiviral use and risk-reduction strategies. Now, a longitudinal cohort study of 1975 SOTRs with diagnoses between March 2020 and May 2023 shows how outcomes and risk factors for COVID-19 progression have evolved over the pandemic's course. Participants were temporally stratified by SARS-CoV-2 variant into one wildtype/Alpha/Delta wave and five Omicron waves.

Severe COVID-19 (defined as need for supplemental oxygen) occurred in 45% of cases during the wildtype/Alpha/Delta wave and subsequently plateaued at about 5% after the Omicron BA.2 wave (beginn…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

COVID-19 Risk and Outcomes Among Solid Organ Transplant Recipients: A Mixed Picture

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Reviewing Author