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Transcatheter aortic valve replacement (TAVR) has demonstrated similar short-term and intermediate-term outcomes compared with surgical aortic valve replacement (SAVR) across the spectrum of surgical risk. As a result, TAVR carries a Class I recommendation in both U.S. and European guidelines for most older patients with severe, symptomatic aortic stenosis. Nonetheless, concerns remain regarding the interpretation of previous trials, which were industry-funded, required use of specific TAVR valves, and allowed for concomitant coronary-artery bypass grafting in the SAVR group (which is known to increase short-term risk).
To address these issues, investigators in Germany performed a manufacturer-independent, multicenter, randomized trial (NCT0…