What Predicts Phenoconversion from Pure Autonomic Failure to a Neurodegenerative Disease?

A natural history study identified clinical features that increased the risk for phenoconversion to an alpha-synucleinopathy in those with pure autonomic failure.

Pure autonomic failure (PAF) can lead to one of the neurodegenerative alpha-synucleinopathies. In this multicenter, longitudinal cohort study, researchers examined clinical features associated with phenoconversion to Parkinson disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA) in 209 participants with pure autonomic failure (64% men; median age, 70 years). Diagnosis of PAF, PD, DLB, or MSA was based on established criteria. Clinical assessments included motor, sleep, olfactory, cognitive, and autonomic measures at enrollment and at yearly follow-up visits. Exclusion criteria included other medical conditions (e.g., diabetes mellitus, amyloidosis) that can cause peripheral autonomic neuropathy; an existing diagno…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

What Predicts Phenoconversion from Pure Autonomic Failure to a Neurodegenerative Disease?

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Reviewing Author