Earlier Thrombolysis Increases the Chance of Reperfusion

Earlier administration of thrombolysis and use of tenecteplase each independently increased the odds of reperfusion for patients with acute stroke.

Previous studies have demonstrated that the earlier administration of a thrombolytic agent in patients with acute ischemic stroke increases the chance of reperfusion. In patients with large-vessel occlusion, limited data are available comparing the rate of reperfusion with alteplase (t-PA) to the rate with tenecteplase (TNK). These authors combined the results of four data sources (three clinical trials and one stroke registry) and assessed angiographic reperfusion following thrombolytic administration. Reperfusion was defined as >50% reperfusion or absence of retrievable thrombus at the time of initial angiography or repeat computed tomographic angiography.

The four data sources included a total of 846 patients (mean age, 73 years; 45% wome…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Earlier Thrombolysis Increases the Chance of Reperfusion

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Reviewing Author