More Data on Thrombectomy with a Large Stroke Volume at Baseline

Another trial in patients with large core infarcts shows improved results with thrombectomy but relatively high rates of death or dependency.

Several clinical trials have shown improved outcomes with the use of endovascular thrombectomy (EVT) for acute stroke in patients with large volumes of ischemic tissue at baseline. These trials have varied with respect to the imaging methods used and the size of the pretreatment ischemic core. Now, researchers have compared EVT plus medical therapy to medical therapy alone in patients who could be treated within 6.5 hours of stroke onset and had a large amount of ischemic tissue (defined by an Alberta Stroke Program Early Computed Tomography Score [ASPECTS] of ≤5). The primary outcome was the modified Rankin scale (mRS) score and the major safety outcome was all-cause mortality, both at 90 days.

During a 3-year period, 333 patients were enro…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

More Data on Thrombectomy with a Large Stroke Volume at Baseline

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Reviewing Author