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Many antibodies have been well characterized in autoimmune encephalitis (AE) and are testable commercially in serum and cerebrospinal fluid (CSF). Some patients are seropositive for an antibody of unknown antigen specificity, a common reference lab finding. Researchers have now developed a protein array platform (for which they have a patent pending) that contains 80% of canonical human proteins to screen for otherwise unclassified neural antibodies.
Of 379 samples of serum and CSF with an unclassified antibody identified over a 1-year period at a reference laboratory, 1 serum sample had an antibody to calmodulin kinase–like vesicle-associated protein (CAMKV). Review of archived samples identified four patients with identical, cerebrum-domin…