Is High Lipoprotein(a) Associated with Risk for First MI in a Low-Risk Population?

Observational data show an association, regardless of the presence or number of other modifiable cardiovascular risk factors.

Lipoprotein(a) [Lp(a)] is associated with coronary artery disease and myocardial infarction (MI) in genetic and epidemiologic studies; however, Lp(a) risk within the context of modifiable cardiovascular risk factors is not well studied.

In the current retrospective analysis, investigators assessed risk for acute first MI among 6238 adults with an Lp(a) measurement taken during routine care and no known atherosclerotic cardiovascular disease. Standard modifiable risk factors for first myocardial infarction were diabetes, dyslipidemia, hypertension, and smoking. High Lp(a) was defined as a value above the 90th percentile and low Lp(a) below the 50th percentile in the cohort.

During a median follow-up of 9 years, 4% of patients experienced an in…

Reviewing Author

Shea E. Hogan, MD, MSCS, FACC, FSCAI, FSVM

Disclosures

Editorial BoardsVascular Medicine

Shea E. Hogan, MD, MSCS, FACC, FSCAI, FSVM

Disclosures

Editorial BoardsVascular Medicine

Is High Lipoprotein(a) Associated with Risk for First MI in a Low-Risk Population?

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Reviewing Author