Mild Cognitive Impairment and Dementia in Essential Tremor Cohort

A longitudinal study tracked conversion rates to MCI and dementia.

Cognitive impairment has been shown to occur in many essential tremor (ET) cohorts. What has been lacking is a better understanding of conversion to mild cognitive impairment (MCI) and potentially dementia. These authors conducted neuropsychological testing and divided their cohort of 222 patients with ET (mean age, 79 years) into those with normal cognition, mild cognitive impairment, or dementia at baseline. Evaluations were repeated for 177 of the patients at 18, 36, 54, and 72 months.

The cumulative prevalence of dementia was 18.5%. The annual conversion rate from ET with normal cognition to ET with MCI was 3.9%, and the conversion rate from ET with MCI to ET with dementia was 12.2%. Compared with historical data, the conversion rate fro…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)