Does Meningococcal Group B Vaccination in the Setting of DoxyPEP Reduce Incidence of Gonorrhea?

A French trial confirmed that doxycycline postexposure prophylaxis reduced incidence of chlamydia and syphilis, but meningococcal group B vaccine was not effective against gonorrhea.

Doxycycline postexposure prophylaxis (DoxyPEP) reduces incidence of chlamydia and syphilis among men who have sex with men (MSM) but has shown lower efficacy against gonorrhea (probably due to tetracycline resistance in Neisseria gonorrhoeae). Meningococcal group B (4CMenB) vaccination may lower incidence of gonorrhea. To test the efficacy of DoxyPEP against chlamydia and syphilis and of 4CMenB against gonorrhea among MSM who were receiving HIV preexposure prophylaxis and had a history of a bacterial sexually transmitted infection (STI) within the past 12 months, investigators in Paris conducted an open-label randomized trial in which participants were randomized to DoxyPEP (200 mg orally within 72 hours of condomless sex) or no DoxyPEP or …

Reviewing Author

Carlos del Rio, MD

Disclosures

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines

Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)

Carlos del Rio, MD

Disclosures

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines

Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)

Does Meningococcal Group B Vaccination in the Setting of DoxyPEP Reduce Incidence of Gonorrhea?

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Reviewing Author