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Due to the heritability of Alzheimer disease (AD), researchers investigated whether parental cognitive history was associated with neocortical [18F]florbetapir amyloid-beta (Aβ) uptake on positron emission tomography in 4413 cognitively unimpaired older adults (mean age, 71 years; 59.3% female). The researchers obtained participant-reported parental history of dementia or significant memory impairment, parental age of memory impairment onset, and the presence of a parental clinical or autopsy-proven AD diagnosis. Additional outcomes included a cognitive composite score.
Memory impairment in the mother or in both parents was associated with both increased amyloid uptake and classification as Aβ-positive based on an established cut-off, compar…