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Total-body computed tomography (CT) often is used to evaluate patients with fever of unknown origin (FUO; defined as temperature >38.3°C on multiple occasions, symptom duration of ≥3 weeks, and no diagnosis after extensive evaluation) and inflammation of unknown origin (IUO; defined as prolonged inflammatory syndrome without fever but with elevated acute-phase reactants such as C-reactive protein). In this systematic review and meta-analysis of 36 studies that involved 3500 patients, researchers evaluated the contributory effect of positron-emission tomography CT (PET-CT) in diagnosing causes of FUO or IUO. PET-CT was defined as contributory if was positive and led to a final diagnosis or if it was completely negative (in accord with a fina…