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More than a decade ago, two small case-control studies suggested an association between some antihypertensive drugs and chronic eczematous dermatitis in older adults. Both studies showed excess risk for eczema in patients taking calcium-channel blockers; one study also showed an association with thiazide diuretics (NEJM JW Dermatol Jan 2008 and J Invest Dermatol 2007; 127:2766; NEJM JW Gen Med Jun 15 2013 and JAMA 2013; 149:814). To explore this association further, researchers analyzed electronic health records of ≈1.5 million older patients (age, ≥60) from primary care practices across the U.K.
After adjustment for confounders, new diagnoses of eczema were 29% more common in patients who initiated antihypertensive drugs. Diuretics and calc…