Atypical Immune Response to SARS-CoV-2 May Induce MIS-C

In patients with MIS-C, an immune response targeted a SARS-CoV-2 epitope that cross-reacted with a host protein involved in antiviral defense.

Multisystem inflammatory syndrome in children (MIS-C) was primarily seen early during the COVID-19 pandemic, yet its pathophysiology has remained unclear. Now, investigators have performed an investigation involving 199 children with MIS-C following SARS-CoV-2 infection and 45 with SARS-CoV-2 infection without MIS-C (at-risk controls) and have confirmed an aberrant immune response as a trigger for developing MIS-C.

The researchers analyzed proteome-wide autoantibody profiles and found that antibodies targeting peptides within three intracellular proteins, including sorting nexin 8 (SNX8; a protein associated with host defenses against RNA viruses), were highly enriched in those with MIS-C. They further found that autoantibodies against SNX8 …

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Atypical Immune Response to SARS-CoV-2 May Induce MIS-C

Topics

Reviewing Author