Options for Patients with Atrial Fibrillation and Stroke Despite Anticoagulation

In a registry study, left atrial appendage occlusion showed promise for patients with atrial fibrillation who experienced stroke while on anticoagulation.

For most patients with atrial fibrillation (AF), treatment with oral anticoagulation (OAC) is recommended for long-term stroke prevention. Despite OAC treatment, some patients will experience breakthrough embolic events. These patients are at high risk for further recurrent events, and improved treatment options are welcome. In this study, authors conducted a propensity-method analysis in which patients with AF who underwent left atrial appendage (LAA) occlusion after having an ischemic stroke or other thromboembolic event while receiving OAC treatment were matched with patients who continued with OAC therapy after a thromboembolic event. All patients had at least 3 months of follow-up data. The primary outcome was time to recurrent ischemi…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Options for Patients with Atrial Fibrillation and Stroke Despite Anticoagulation

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Reviewing Author