Can a Novel Stent Design Improve Long-Term Outcomes of Percutaneous Coronary Intervention?

A large-scale randomized trial from Sweden suggests the answer may be yes, but long-term follow-up is essential.

Compared with bare metal stents (and balloon angioplasty), drug-eluting stents (DES) have markedly improved the outcomes of percutaneous coronary intervention (PCI), mainly through reductions in restenosis due to neointimal hyperplasia, generally seen during the first year after PCI. However, current-generation DES experience late failure at approximately 2% annually through 5 years and probably indefinitely, likely caused (partly at least) by ongoing vascular injury from the metallic implant. Swedish investigators have now performed an industry-funded, randomized trial comparing a novel drug-eluting scaffold, the DynamX bioadaptor, with a current-generation DES in 2399 patients (median age, 70; 24% women) undergoing PCI for stable or unsta…

Reviewing Author

David J. Cohen, MD, MSc

Disclosures

Consultant/Advisory BoardMedtronic; Edwards Lifesciences; Abbott Vascular; Boston Scientific; St. Francis Hospital

Speaker’s BureauBoston Scientific; ZOLL Medical

Grant/Research SupportEdwards Lifesciences; Abbott Vascular; Boston Scientific; Corvia Medical; National Heart, Lung, and Blood Institute; Phillips, Inc.; St. Paul’s Hospital; V-Wave, Inc; ZOLL Medical; CathWorks, ANCORA

Editorial BoardsJACC; American Heart Journal; EuroIntervention; JSCAI; Structural Heart Journal

Leadership Positions in Professional SocietiesSociety of Thoracic Surgeons/American College of Cardiology TVT Registry (Co-Chair, Risk Model Development Committee); Cardiovascular Research Foundation (Co-Director, TCT Annual Meeting; Co-Director, New York Valves Annual Meeting)

David J. Cohen, MD, MSc

Disclosures

Consultant/Advisory BoardMedtronic; Edwards Lifesciences; Abbott Vascular; Boston Scientific; St. Francis Hospital

Speaker’s BureauBoston Scientific; ZOLL Medical

Editorial BoardsJACC; American Heart Journal; EuroIntervention; JSCAI; Structural Heart Journal

Can a Novel Stent Design Improve Long-Term Outcomes of Percutaneous Coronary Intervention?

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Reviewing Author