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Primary care management of polycystic ovarian syndrome (PCOS) focuses on preventing complications of chronic anovulation and encouraging weight loss. Although ≈50% of women with PCOS have overweight or obesity, the effects of weight loss on PCOS symptoms and laboratory markers remain unclear. Researchers conducted a meta-analysis of randomized trials in which investigators examined the effect of weight loss by behavioral interventions (12 studies) or weight-loss drugs (17 studies) in patients with PCOS.
Weight loss interventions resulted in an average weight loss of −3.8 kg, which was associated with less insulin resistance and free androgen index values. Menstrual frequency improved significantly, with an average of 2.6 additional cycles an…