Individual therapy sessions were not superior to modafinil.
Fatigue is a common, disabling, and frustrating multiple sclerosis (MS) symptom. Pharmacologic and behavioral interventions have been studied in treating MS fatigue; their combination effects have not been evaluated. Investigators evaluated the effects of cognitive behavioral therapy (CBT), modafinil, and their combination in patients with MS who had significant fatigue according to the Modified Fatigue Impact Scale (MFIS; score of >4) at baseline. CBT consisted of 10 total one-on-one sessions by telephone, with emphasis on sleep hygiene and behaviors, physical activity, and activity pacing. The 336 participants were randomized to the three arms, with both patients and clinicians unblinded to the treatment assignments.
At 12 weeks, scores on…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)