Optimization of Anti-MAG Testing in Patients with Neuropathy

The typical phenotype of polyneuropathy with IgM paraprotein and antibodies targeting myelin-associated glycoproteins (anti-MAG neuropathy) is a chronic distal and sensory-predominant demyelinating neuropathy that can mimic chronic immune demyelinating polyradiculoneuropathy (CIDP). In this retrospective single-center study of 752 adult patients with suspected neuropathy who were previously tested for anti-MAG antibodies, researchers established optimal anti-MAG titers for excluding CIDP and for distinguishing typical from atypical axonal anti-MAG neuropathy. They used the commercially available Bühlmann enzyme-linked immunosorbent assay for anti-MAG antibodies. The manufacturer recommended cutoff of positivity is 1000 Bühlmann titer units …