Cryptococcosis Outcomes in People Without HIV Infection

Compared with patients infected with Cryptococcus neoformans, those with C. gattii infection had lower mortality but were more likely to develop CNS disease–related immune response inflammatory syndrome.

Cryptococcosis is increasingly recognized in those without HIV and entails infection with either Cryptococcus neoformans or C. gattii. In 2023, a consortium of 46 hospitals in Australia and New Zealand reported outcomes among 426 patients without HIV infection, representing 90% of all cases. That study found that almost 40% of patients had no documented immunocompromising condition, higher serum cryptococcal antigen titers were associated with CNS involvement, 1-year all-cause mortality was 21%, and C. gattii comprised 26% of culture-positive cases.

Now the researchers assessed management and the predictors of mortality in that same cohort. Infection with C. gattii was associated with lower risk for death than was infection with C. neoforman…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Cryptococcosis Outcomes in People Without HIV Infection

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Reviewing Author