Adjuvant Therapy for High-Risk Stage II Colon Cancer

Given the relatively low risk of recurrence after resection of stage II colon cancer, treatment guidelines include consideration for observation alone or adjuvant chemotherapy. Patients with stage II disease and features including a T4 primary tumor, presentation with perforation or obstruction, or inadequate lymph sampling at surgery have a higher risk for recurrence and are more strongly considered for adjuvant chemotherapy. The adjuvant treatment of patients with high-risk stage II colon cancer with fluorinated pyrimidine (FP) alone or with the addition of oxaliplatin remains controversial.

Investigators now report an ACCENT database pooled analysis of data from the MOSAIC and C-07 randomized trials comparing 6 months of adjuvant FP-based…