Adjunctive Thrombolysis Tested After Posterior Circulation Thrombectomy for Acute Ischemic Stroke

In a randomized trial, use of intra-arterial tenecteplase following thrombectomy was not associated with an improved outcome.

Despite the use of mechanical thrombectomy (MT) for patients with acute ischemic stroke in the posterior circulation (distal vertebral artery or basilar artery), outcomes are not satisfactory for most patients. Whether injecting a thrombolytic agent following thrombectomy to treat residual clots or improve microcirculatory flow improves outcomes is unknown. These authors conducted a randomized trial in China, enrolling 208 patients (mean age, 66 years; 25% women) with acute stroke involving major vessels of the posterior circulation (distal vertebral artery, basilar artery, proximal posterior cerebral artery). After successful thrombectomy, patients were randomly assigned to intra-arterial tenecteplase (0.0625 mg/kg; maximum, 6.25 mg) or st…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Adjunctive Thrombolysis Tested After Posterior Circulation Thrombectomy for Acute Ischemic Stroke

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Reviewing Author